Manoela Romanó de Orte's research embraces a comprehensive perspective of pollution, one that considers legacy contaminants, such as heavy metals, alongside emerging contaminant threats, such as pharmaceuticals and microplastics. She is particularly interested in understanding how these contaminants interact with ocean acidification and warming. For instance, in a recent study, She showed that when sea anemones are bleached by hot ocean temperatures, they are more likely to ingest and retain plastic microfibers. Her work has also shown that ocean acidification can increase the mobility of heavy metals from sediment to seawater, as well as their bioavailability and toxicity to marine microalgae.