The eukaryotic ribosome is a complex molecular machine responsible for the translation of mRNA to protein. Over the years we have gained detailed knowledge of ribosome structure, function, and biogenesis; however, a major unanswered question in the translation field is how cells monitor the integrity of the ribosome itselfAlterations in ribosome structure and function have been associated with diseases such as neurodegeneration, cancer, and ribosomopathies. Indeed, mutations, environmental stress, or mistakes during assembly can lead to malfunctioning ribosomes that need to be detected and marked for degradation to maintain translation fidelity. My group capitalizes on the recent advances in quantitative mass spectrometry, functional genomics methods, and CRISPR-mediated genome editing to study the molecular mechanisms of ribosome surveillance.

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A Virtual Conversation with Cell Biologist Kamena Kostova


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